UTI Treatment

Empiric Treatment for Uncomplicated LUTI


  • Nitrofurantoin 100mg BID x 5 days
  • Trimethoprim-sulfamethoxazole 160/800mg (one DS tab) BID x 3 days

Other options:

  • Cephalexin 500 mg QID x 3-5 days
  • Amoxicillin-clavulanate 500/125mg q8h OR 875/125mg q12h x 3-5 days


  • Fluoroquinolones – increased risk of selecting out for resistant organisms, C. Diff
  • Amoxicillin/Ampicillin monotherapy – increased risk of resistance


  • Tailor treatment to culture results

Empiric Treatment for Severe Symptoms (i.e. pyelonephritis)

  • Ceftriaxone 1g IV q24h (step-down to oral agent when clinically appropriate and tailor treatment to culture results)

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