Skin and Soft Tissue Infections

Common Pathogens

Streptococci (mostly group A, but also B, C or G), S. aureus

Treatment Options

 Empiric Treatment for Cellulitis

IV therapy

  • Cefazolin 1-2g q8h
  • MRSA or severe penicillin allergy:  Vancomycin

PO therapy

  • Cephalexin 500mg qid OR amoxicillin-clavulanate 875/125 q12h
  • MRSA:  doxycycline 100mg BID OR septra DS 1-2 tabs BID (verify susceptibilities first)

Clinical Pearls

  • Switch to PO medications as soon as clinically appropriate
  • Duration can be as short as 5 days for uncomplicated cellulitis
  • Cellulitis does not present bilaterally.
  • Elevation of the affected area can both help to rule out cellulitis, and quicken resolution of an actual infection.
  • Cellulitis response to treatment may worsen initially, but will gradually stabilize and improve.

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