AECOPD Empiric Treatment

Treatment Options

Simple Exacerbation

  • amoxicillin 1g PO TID x 5 days
  • doxycycline 100mg PO BID x 5 days
  • co-trimoxazole DS 1 tab PO BID x 5 days
  • azithromycin 500mg 1 tab PO daily x 3 days

Complicated Exacerbation

  • amoxicillin/clavulanate 875/125mg PO BID x 5 days

AECOPD + Pneumonia

  • Ceftriaxone 1 gram IV daily x 7 days and azithromycin 500mg IV daily for 1 day then 500mg IV or PO daily x 4 days
  • Amoxicillin/clavulanate 875/125mg PO BID x 7 days and azithromycin 500mg PO daily x 5 days

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